Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metal-chelating age...
متن کاملThe Interaction between Metals and Chelating Agents in Mammalian Spermatozoa
Several studies have been made on the bacteriostatic and fungicidal properties of oxine (8-hydroxyquinoline) and other chelating agents, and it has been suggested that they might act, in part at least, by depriving cells of essential trace metals (Albert, 1951; Martell & Calvin, 1952). In an attempt to determine the trace element requirements of mammalian spermatozoa, White (1955) investigated ...
متن کاملMobilization of heavy metals by newer, therapeutically useful chelating agents.
Four chelating agents that have been used most commonly for the treatment of humans intoxicated with lead, mercury, arsenic or other heavy metals and metalloids are reviewed as to their advantages, disadvantages, metabolism and specificity. Of these, CaNa2EDTA and dimercaprol (British anti-lewisite, BAL) are becoming outmoded and can be expected to be replaced by meso-2,3-dimercaptosuccinic aci...
متن کاملExtraction Heavy Metals from Contaminated Water Using Chelating Agents
Water pollution caused by toxic elements is one of the most important environmental problems in the world. Heavy metals are toxic to human and dangerous for the environment. The objectives of this study were: the effects of chelating agents on heavy metals extraction from polluted water were carried out to examine. In different concentrations : 0.01, 0.05, 0.1 mg/l of Chelating agents: Ethylene...
متن کامل3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases.
Monoamine oxidase (MAO) generates reactive oxygen species (ROS), which cause neuronal cell death, causing neurodegeneration. Agents that are able to concurrently inhibit MAO and scavenge free radicals represent promising multifunctional neuroprotective agents that could be used to delay or slow the progression of neurodegenerative diseases. In this work, variously substituted 3-amidocoumarins a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Dalton Trans.
سال: 2010
ISSN: 1477-9226,1477-9234
DOI: 10.1039/b919237a